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It is worth noting that some corals are currently listed as endangered on CITES and IUCN lists, such as Antipatharia ※ , Tubiporidae ※ , Corallium elatius ※ , Corallium japonicum ※ , Corallium konjou ※ , and Corallium secundum ※ , ensuring that a balance between the sustainability of scientific research and the protection of endangered species is a complex but crucial task

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Initially it was believed that each bitter-sensitive type II TRC expressed every TAS2R isoform (Adler et al., 2000) but other studies suggest that TAS2Rs can be expressed differentially, allowing for possible discrimination among bitter compounds (Caicedo and Roper, 2001